Ozone therapy is typically performed on an outpatient basis, offering flexibility for patients to integrate sessions into their routine. Prior to therapy, patients may be advised to fast briefly and discontinue certain medications, while hydration is emphasized.

Ozone therapy encompasses several administration techniques, each tailored to suit different medical conditions and patient needs. These methods include skin exposure to ozone gas (ozone sauna), topical application of ozone solutions, insufflation through body orifices, mixing ozone with blood for intravenous reintroduction (autohemotherapy), ingestion via ozonated oil or water, and intramuscular injection.

The duration of a session varies depending on the method, with ozone sauna sessions lasting 20 to 60 minutes and intravenous procedures taking approximately 30 to 60 minutes. Post-therapy, patients should adhere to post-procedural care instructions, including hydration and avoiding strenuous activity. Throughout the session, healthcare providers monitor patients closely for adverse reactions, ensuring safety and providing prompt intervention if needed.